Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats

چکیده

Low doses of Bisphenol A (BPA) during development may affect reproduction.‎ In this study, Fischer 344 rats were exposed to 0.‎5 or 50 μg BPA/kg bw/day via drinking water from gestational day 3.‎5 to postnatal day 22.‎ Anogenital distance, organ weight, histopathology of reproductive organs, hormone analysis and sperm morphology were evaluated in male offspring.‎ In this study no major effects of BPA on male reproduction in midpubertal (postnatal day 35) or adult (12-month-old) rats were revealed, apart from a higher prevalence of mild inflammatory cell infiltrate in cauda epididymis in adult rats exposed to 50 μg BPA/kg bw/day.‎ No BPA-related effects on sexual development were seen but care should be taken when evaluating histopathology in midpuberty testis due to large morphological variation.‎ Results from the present study show no major signs of altered male reproduction in rats exposed to low doses of BPA during gestation and lactation.‎

استناد: 

Spörndly-Nees, Ellinor, Julie Boberg, Elisabeth Ekstedt, Lena Holm, Azadeh Fakhrzadeh, Linda Dunder, Mark M.‎ Kushnir, Margareta H.‎ Lejonklou, P.‎ Monica Lind.‎ 2018.‎ Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats.‎ Reproductive Toxicology ۸۱ (۱۹۶-۲۰۶).

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